From Cells to Organs: Exploring Variability in Physiological Systems

Lead CI:   Kevin Burrage

Everyone is different, and every heart is different and thus variability is a common feature of all physiological systems. This variability manifests itself at all levels in all organs of living organisms: from ionic mechanisms to long range electrical activity. In addition, biological tissue is heterogeneous at a variety of different spatial and temporal scales and one of the key issues in physiology is how structure affects function. This project will explore this variability and the issue of how structure affects function in both the brain and the heart using state of the art modeling, simulation, data analytics and visualization approaches. New models, new simulations and new data analytics techniques will be developed that are calibrated against a variety of experimental data. The project will have a number of components.